Chemotherapy[ edit ] Methotrexate was originally developed and continues to be used for chemotherapyeither alone or in combination with other agents. It is effective for the treatment of a number of cancers, including: Because of its effectiveness, low-dose methotrexate is now first-line therapy for the treatment of rheumatoid arthritis. It is also used to treat ectopic pregnanciesprovided the fallopian tube has not ruptured.
Definition[ edit ] "Folate" is the term used to name the many forms of the vitamin — namely folic acid and its congenersincluding tetrahydrofolic acid the activated form of the vitaminmethyltetrahydrofolate the primary form found in the serummethenyltetrahydrofolate, folinic acid, and folacin.
In this usage, "folate" is just "folic acid" in a non-acidic solution. Health effects[ edit ] Folate is necessary for the production and maintenance of new cellsfor DNA synthesis and RNA synthesis through methylationand for preventing changes to DNAthus for preventing cancer.
Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. RNA transcription and subsequent protein synthesis are less affected by folate deficiency, as the mRNA can be recycled and used again as opposed to DNA synthesis, where a new genomic copy must be created.
Since folate deficiency limits cell division, erythropoiesisproduction of red blood cellsis hindered and leads to megaloblastic anemiawhich is characterized by large, immature red blood cells.
This pathology results from persistently thwarted attempts at normal DNA replication, DNA repair, and cell division, and produces abnormally large red cells called megaloblasts and hypersegmented neutrophils with abundant cytoplasm capable of RNA and protein synthesis, but with clumping and fragmentation of nuclear chromatin.
Some of these large cells, although immature reticulocytesare released early from the marrow in an attempt to compensate for the anemia.
NTDs occur early in pregnancy first monththerefore women must have abundant folate upon conception. Folate is required to make red blood cells and white blood cells and folate deficiency may lead to anemiawhich causes fatigueweakness and inability to concentrate. It contributes to spermatogenesis.
Therefore, receiving sufficient amounts through the diet is necessary to avoid low fertility.
Read our reviews about B vitamin supplements, including B complexes, niacin, B-6, B, biotin, Thiamin and Folic acid, plus information about B vitamins for energy, memory, depression, MTHFR and methylfolate, and the safety of energy drinks with B vitamins. Find out which one passed the test. Indications for Folic acid: Megaloblastic anemias of folic acid deficiency. Anemias of nutritional origin, pregnancy, infancy or childhood. Adults and Children. INTRODUCTION. This topic review discusses the symptoms, clinical manifestations, and diagnosis of vitamin B12 and folate deficiency, vitamins that are required for .
Folic supplements are inexpensive and relatively safe to use, which is why people who have had strokes or who have hyperhomocysteinemia are encouraged to consume daily B vitamins including folic acid. The antifolate drug methotrexate is often used to treat cancer because it inhibits the production of the active form of THF from the inactive dihydrofolate DHF.
However, methotrexate can be toxic,    producing side effects, such as inflammation in the digestive tract that make eating normally more difficult. Also, bone marrow depression inducing leukopenia and thrombocytopenia and acute kidney and liver failure have been reported.
Folinic acidunder the drug name leucovorina form of folate formyl-THFcan help "rescue" or reverse the toxic effects of methotrexate.
Folic acid supplements have little established role in cancer chemotherapy. Anyone receiving methotrexate should follow medical advice on the use of folic or folinic acid supplements.
Español | 日本語. Summary. Folate is a generic term referring to both natural folates in food and folic acid, the synthetic form used in supplements and fortified food. Folate is critical in the metabolism of nucleic acid precursors and several amino acids, as well as in methylation reactions. (More information). Adequate intake of folic acid during pregnancy is very important for the health of the mother and her baby. Clinical evidence shows that fetal neural defects can be prevented with folic acid supplementation in folic acid deficient mothers. Folic acid, folate, vitamin B9 (FA-8, Folacin, Folic Acid, GNC Folic Acid , and many more) is used for the treatment of folate deficiency and its complications, and for the treatment of folic acid deficiency associated with liver disease, kidney dialysis, ulcerative colitis, and alcoholism.
The supplement of folinic acid in people undergoing methotrexate treatment is to give cells dividing less rapidly enough folate to maintain normal cell functions. The amount of folate given is depleted by rapidly dividing cells cancer quickly, so does not negate the effects of methotrexate. Neurological[ edit ] Some evidence links a shortage of folate with depression.Folate, the natural form of folic acid, is found in food, while folic acid is produced by chemical processes to be used commercially in supplementation and foods.
Folic acid alone is not pharmacologically active, its activity is due to tetrahydrofolate after conversion by the liver to dihydrofolic acid.
«ACCESS YOUR DIRTY GENES COURSE and SUMMIT Here» PS- If you don’t know your password click the "Forgot Password" under the Sign In button. We . If I asked you which of these vitamins was found naturally in food, folate or folic acid, would you know the answer?
If not, you’re in good company. Medical professionals, nutrition experts, and health practitioners frequently mix up the two, simply because the terms are often used interchangeably. Many health professionals would even argue that folate and folic acid are essentially the same.
Folate, distinct forms of which are known as folic acid, folacin, and vitamin B 9, is one of the B vitamins. It may be taken by mouth or by injection.
The recommended adult daily intake of folate in the U.S. is micrograms from foods or dietary supplements. Folate in the form of folic acid is used to treat anemia caused by folic acid deficiency. Folic acid is also used as a supplement by. Citric acid is a naturally occurring acid which is found in large quantities in fruits – notably citrus fruits such as oranges, lemons and certain berries.
It is a relatively weak acid and has a distinct, sour taste.
Overview Information Folate and folic acid are forms of a water-soluble B vitamin. Folate occurs naturally in food, and folic acid is the synthetic form of this vitamin. Since , folic acid has.